〜をはじめ
starting with, including (and others)
Noun + をはじめ / をはじめとして · をはじめとする + Noun
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をはじめ leads a list with its most important or typical member, and implies there are others: 東京をはじめ、大きな町はどこも込んでいる, "big cities, starting with Tokyo, are crowded everywhere".
It's a formal way to say "X and others" or "including, above all, X". You'll hear it in speeches and thank-yous: 社長をはじめ、社員全員, "everyone from the president down".
をはじめとして means the same. Before a noun, it becomes をはじめとする: 京都をはじめとする古い町, "old towns such as Kyoto".
The はじめ is the noun "beginning", related to 始める. Compare など, which goes after a list and adds "and so on" without singling anything out.
Examples
東京をはじめ、大きな町はどこも込んでいる。
Big cities, starting with Tokyo, are crowded everywhere.
社長をはじめ、社員全員がパーティーに参加した。
Everyone from the president down came to the party.
すしや天ぷらをはじめ、日本料理は世界中で人気だ。
Japanese food, with sushi and tempura leading the way, is popular all over the world.
両親をはじめ、多くの人に助けてもらった。
I was helped by many people, above all my parents.
京都をはじめとする古い町を旅行した。
I travelled around old towns, Kyoto among them.