〜はさておき
setting aside, leaving aside
Noun + はさておき · 何はさておき
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はさておき sets one topic aside to focus on a more important one: 冗談はさておき、本題に入りましょう, "joking aside, let's get down to business".
It's close to はともかく (N2) and は別として (N2), and often interchangeable. はさておき feels like deliberately postponing a topic for now, often in conversation or meetings.
何はさておき is a fixed phrase meaning "before anything else, first of all": 何はさておき、まずは食事にしよう, "first things first, let's eat".
さておく means "to put aside". Compare はもちろん (N2), "of course (and)", which includes rather than sets aside.
Examples
冗談はさておき、本題に入りましょう。
Joking aside, let's get down to business.
値段はさておき、デザインが気に入らない。
Leaving the price aside, I don't like the design.
何はさておき、まずは食事にしよう。
First things first, let's eat.
結果はさておき、よく頑張った。
Whatever the result, you did really well.
細かいことはさておき、大筋では賛成だ。
Leaving the details aside, I agree in principle.