〜上は
now that, since (so I must)
Verb plain form (often た-form) + 上は
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上は means "now that this is the situation, it follows that…": 引き受けた上は、最後まで責任を持ちます, "now that I've taken it on, I'll see it through responsibly".
It's a formal, written relative of からには (N3). The first half is a decision, a commitment or an unavoidable situation. The second half is what that obliges you to do, or a strong resolve: なければならない, べきだ, つもりだ, しかない.
Most often it follows a た-form, because the commitment has already been made: 契約した上は, 決めた上は, 選ばれた上は.
Don't confuse it with 上で (N3), "after (and based on)", or 上に, "on top of". The particle は is what makes this one "now that".
Examples
引き受けた上は、最後まで責任を持ちます。
Now that I've taken it on, I'll take responsibility for it to the end.
契約した上は、ルールを守らなければならない。
Now that you've signed the contract, you have to follow the rules.
こうなった上は、覚悟を決めるしかない。
Now that it's come to this, I have no choice but to brace myself.
試験を受けると決めた上は、毎日勉強するつもりだ。
Now that I've decided to take the exam, I intend to study every day.
代表に選ばれた上は、全力を尽くします。
Having been chosen as representative, I'll give it everything I've got.